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Wednesday, 07 March 2012 17:16

Four Doses of PrEP a week may be enough to protect

Four Doses of PrEP a week may be enough to protect

The below statement was written by Gus Cairns and published at AIDSMAP.COM.

It makes the claim upon review of the data collected during the iPrex studies, which our friend Dr. Ken Mayer from Brown University and the Fenway Community Health Center here in Boston was a part of orchestrating, that four doses of Truvada a week instead of dosing every single day is sufficient to prevent transmission of HIV.

This is great news. It is still our opinion at Search For A Cure that eventually there will be consensus that one dose, once, the day of a possible exposure will be sufficient to prevent transmission and we will continue to push the clinicians to seek out demonstration of that empirically.

Four doses of PrEP a week may be enough to protect

PrEP >

Gus Cairns

Published: 06 March 2012

Detail from iPrEx materials (www.globaliprex.com).

Further testing of drug levels in the blood and immune cells of gay men participating in the iPrEx trial of tenofovir/FTC (Truvada) pre-exposure prophylaxis (PrEP) has found that HIV infection in men assigned to Truvada was associated with a lapse in taking the drug after initially adhering reasonably well, rather than never having taken it at all, which was what the researchers originally thought. The research was presented at the 19th Conference on Retroviruses and Opportunistic Infections (CROI), in Seattle.

The testing also found that only a minority of participants appeared to be taking their drugs as prescribed, seven days a week, but that protection levels were very high – in the order of 96% of infections prevented – as long as participants took four or more doses a week.

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